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In this paper, we propose a novel method for building a tailored scoring function using comparative molecular binding energy (COMBINE) descriptors and support vector regression (SVR).
Application of the comparative molecular field analysis (CoMFA), GRID/GOLPE and comparative binding energy (COMBINE) analysis methods permitted the derivation of quantitative structure-activity relationships (QSARs) that aid in identifying the specificity-determining residues within WW domains and their ligand-recognition motifs.
(A) Lie on the bed to rest continuously (B) Save energy, combine work with adequate rest (C) Drinking (D) I don't know Lie on the bed to rest continuously Save energy, combine work with adequate rest Drinking I don't know Would you return to the hospital on time for the chemotherapy on medical advice?
(A) Lie on the bed to rest continuously (B) Save energy, combine work with adequate rest (C) Drinking (D) I don't know (25) Would you return to the hospital on time for the chemotherapy on medical advice?
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In contrast, subsidies to wind and solar energy, combined over this same period, totalled only $5.5bn".
Its driving energy combines with the tart, hard-edged harmonies to create a frenzy that leaves you reeling.
Gollancz had demonic energy, combined with a self-assurance which slipped easily into arrogance ("I am incapable of error").
It is the right level of energy combined with the right attitude that enables us to perform at our best.
Solar panels on the wings might give enough energy, combined with the thermals, for extended flights, he said.
"The cost of energy combined with rising interest rates could jeopardize the pace of economic growth in the coming months," she said.
But for now, China's need for imported energy combined with its desire to diversify its supplies, from the Middle East primarily, is making Indonesia, at least, feel confident.
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