Sentence examples for energy checkpoints from inspiring English sources

The LKB1 ortholog is required to synchronize cellular energy checkpoints and cell division 14, 15.

The significance of LKB1 in energy checkpoints is illustrated by the fact that loss of LKB1 in fibroblasts and in the pancreas is associated with apoptosis in response to energy stress 26, 27.

Because of the role of AMPK as a central energy checkpoint in the cell, these findings link LKB1 signaling to energy metabolism control, positioning LKB1 as a critical mediator of the effects of low energy on cell viability11, 13.

An intuitive function of evolutionary conserved low-energy checkpoints such as the AMPK/mTOR/S6K1 longevity pathway is therefore to suppress cell proliferation by preventing nutrient utilization for anabolic processes [ 7, 8].

We propose that perhaps KRAS activation and LKB1 loss permit liberation from cell cycle and energy status checkpoints, respectively, which allow for a metabolic advantage.

Since AMPK pathway functions as a cellular energy-sensing checkpoint that controls cell proliferation [19], the effects of LETM1 on cell proliferation were measured.

Although the specific mechanisms between mitochondria and the cell cycle regulation is not well understood, studies have shown that low energy cell cycle checkpoints monitor the energy capability before committing to another round of cell division.

ROS have been demonstrated to modulate respiration in mammals by regulating several checkpoints energy pathways and mtDNA homeostasis.

The G1 phase is important during normal development and homeostasis to allow newly-divided cells to increase in size and replenish protein and energy stores; additionally, regulatory checkpoints during G1 control cell fate choices such as the decision to exit the cell cycle and differentiate (Lee and Orr-Weaver, 2003; Hindley and Philpott, 2013).

Alterations in energy availability trigger cell-cycle checkpoints, suggesting a bidirectional connection between cell division and general metabolism.

Some save points are scattered through the world, and the game saves automatically after turning points in the story, but players may have travelled far from the last save before reaching a concentrated area of particularly difficult platforming, and if they don't have enough energy to create their own checkpoint right before their first attempt they'll be faced with repeating that journey.