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There is no energetically responsive residue that is not closely associated with the MIR domain.
The program for the prediction of the energetically responsive residues by the Elastic Net Model is freely available on request from the corresponding author.
In order to interpret the binding of the PKA on RyR2, we performed elastic net analysis of energetically responsive residues of RyR2.
The set of conserved residues, with the highest level of conservation according to Reference 20 of the protein, all lie within the set of energetically responsive residues and are located along or in the neighborhood of the path obtained from the energetically responsive residues.
The path shown in the figure contains the energetically responsive residues predicted by the GNM as may be seen from Figure 3. Using extensive docking calculations and libraries of residues obtained from regulator proteins of the RyR2 channel, we showed that residues 318 323 of PKA have a very high affinity for the N-terminal of RyR2.
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The fundamental idea of ecologic immunology is that maintaining a responsive immune system and mounting an immune response are energetically and nutritionally costly and that these costs have to be balanced against other expenses, such as reproduction, molting, growth, and development, that contribute to an animal's fitness (6, 10 ).
Mr. Walsh apologized energetically.
She shrugs energetically.
That's energetically costly — and deadly.
"It feels," she said, "just energetically perfect.
You could rule out birds flapping energetically.
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