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AmyloidMutants provides the highest accuracy prediction to date of the full fibril structure of amyloid sequences, but its greater value is its unique ability to discover which mutations effect a change in amyloid structure(s), to predict what that structure is and to assign meaningful energetic weights comparing mutant conformations.
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The amyloidogenicity of each mutation is predicted by computing a joint mutational landscape over WT and mutant sequences, and quantifying which sequence more readily forms amyloid according to its energetic weight within the ensemble.
AmyloidMutants sequence/structure landscapes were calculated permitting these four residues to mutate to Gln ('HET-s/4N→Q'), and the likelihood and corresponding energetic weight of each sequence within the ensemble was compared.
It is composed of both "quantity," the mass of self (the posture, body parts, the subsystems) and "quality," the glue or dynamic energetic organization of weight and how that integrates it all together in expression.
The accident, so the story went, had changed Mrs Barrington from a spoiled young newly wed into a resourceful and energetic woman of weight and responsibility in the community".
This present review, however, the techniques applied to energetic materials; drop weight studies which are generally used to determine ignition levels, Hopkinson bar studies in relation to impact scenarios, while plate impact produces stresses associated with detonation.
Healthy women consumed a mid-morning snack consisting of either the test or the control yogurt product (Study 1, n = 24: iso-energetic, not iso-weight conditions; Study 2, n = 121: iso-weight, not iso-energetic conditions) under laboratory conditions.
"Footprints" is a departure from her signature weight-shifting, energetic style.
The weight-specific energetic cost of migration decreases with fish size (see Ware 1978 and Alexander 2003 for general treatments of size-dependent swimming costs in fish).
The consumption of energy in groups II and III was calculated from the volume of ingested formulas within 24 hours, taking into account the body weight and energetic value of consumed milks reported by the manufacturers.
After controlling for potential confounders (viz., age and family income), regression analyses showed that obese boys in grades 3 and 4 had more difficulties running, playing sports, and doing exercise, and were less energetic than their normal-weight counterparts.
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CEO of Professional Science Editing for Scientists @ prosciediting.com