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The VORFFIP (Voronoi Random Forest Feedback Interface Predictor) algorithm [ 40] makes use of atom-resolution 3D Voronoi diagrams [ 243] to identify spatially neighbouring surface residues, for which features are assigned using structural, energetic, evolutionary, and experimental data.
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One key feature is to base the description of individuals' behaviour and interactions on first principles rooted in energetic or evolutionary theory.
PRCPi depends on the integration of structural, energetic, and evolutionary-based measures by using Bayesian Networks (BNs).
A philosopher rather than a biologist, he became an energetic proponent of evolutionary ideas, popularized a number of slogans, such as "survival of the fittest" (which was taken up by Darwin in later editions of the Origin), and engaged in social and metaphysical speculations.
Put another way, oxygen is only 0.2 to 0.02% as important as mitochondria when it comes to covering the energetic costs of evolutionary inventions.
PCRPi [7] overcomes this limitation by combining a set of seven different measures that account for energetic, structural, and evolutionary-based information (Figure 2).
The total electrical work picked up by the VS domains is an order-of-magnitude larger than the work required to actuate the gate itself, suggesting an energetic basis for the evolutionary flexibility of the voltage-gating mechanism.
Future work will explore possible energetic benefits and the evolutionary lability of PSD relative to other mate-limiting reproductive behaviors.
Evolutionary maintenance of introns despite the energetic burden they entail suggests some evolutionary advantage afforded by introns.
Our results confirm the negative correlation between protein length and expression level expected from the energetic costs associated with translation and from evolutionary theory.
It seems that there is an evolutionary trade-off between the energetic costs of maintaining multiple polyploid replicons within a cell and the acquisition by outcrossing of an external template for homologous recombination.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com