Exact(5)
As suggested by this study, this improved communication between ATP supply and demand pathways is likely a key strategy to limit hypoxia-induced energetic alterations.
Whether these amino acid changes are indicative of energetic alterations or increased autophagy is unclear [ 39].
Whereas energetic alterations in heart failure are, in most cases, the consequence rather than the cause of failure, this is likely different in sarcomeric cardiomyopathies.
More importantly, they all point to perturbations in proteins, metabolites and metabolic fluxes reflecting mitochondrial energetic alterations, even in the early stage of the dystrophic pathology.
Collectively, these data point to perturbations in proteins, metabolites and metabolic fluxes that reflect mitochondrial energetic alterations in skeletal and heart muscles at an early stage of the dystrophic pathology.
Similar(55)
In this context, it has been demonstrated that cytokine levels, oxidative stress, and energetic metabolism alterations seen early after sepsis may persist for up to 30 days and this could be associated with cognitive damage [24 26].
Changes in these pathways imply alterations in energetic resource use upon exposure to elevated p CO2.
More recently, Rokyta et al. demonstrated in patients treated with CVVH that cooling over a short period of time was associated with significant decrease in heart rate, cardiac output, systemic oxygen delivery and consumption, as well as increase of the mean arterial pressure without significant alteration of energetic balance [17].
More recently, Rokyta et al. demonstrated in patients treated with CVVH that cooling over a short period of time was associated with significant decrease in heart rate, cardiac output, systemic oxygen delivery and consumption, as well as increase of the mean arterial pressure without significant alteration of energetic balance [ 17].
Mutational robustness (Rm) accounts for structural changes after single-point mutations in the pre-miRNA sequence, whereas environmental robustness (Re) accounts for structural changes after alterations in the energetic parameters implemented in the thermodynamic model for base pair interactions (Layton and Bundschuh 2005).
Here, to shed light on the molecular mechanisms of autophagy induction by cannabinoids in pancreatic adenocarcinoma cells, we have investigated whether the AMPK has a role in this effect and whether this mechanism is related to the alteration of the energetic metabolism.
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