Enduring impairments in processing repetitive stimuli have also been demonstrated by rearing rats in pulsed or notched noises [28], [39].
In conclusion, brain-directed auto-immune responses are likely to interfere with (or produce enduring impairments to) function of brain areas, with all the consequences thereof.
This poor social functioning has been attributable to pervasive and enduring impairments in social cognition [ 5– 10]: the perception, interpretation and processing of socially-relevant information [ 11– 16].
Zola-Morgan, S., Squire, L. R. & Amaral, D. G. Human amnesia and the medial temporal region: enduring memory impairment following a bilateral lesion limited to field CA1 of the hippocampus.
Hyperactivity and reduced cognitive flexibility are patterns of behaviour consistent with enduring functional impairment of striatal regions.
Similarly, lesions of the central thalamus can produce enduring cognitive impairments, including reduced attentional processing and memory (Guberman and Stuss, 1983; Mair et al., 1998; Van Der Werf et al., 1999; Newman and Burk, 2005), hypersomnolence (Bassetti et al., 1996), or even coma (Castaigne et al., 1981; Plum, 1991).
Schizophrenia patients with the deficit syndrome are characterized by primary enduring negative symptoms, impairment on neurocognitive tasks sensitive to frontal and parietal cortical functioning, and poorer functional outcome compared to non-deficit patients.
Trial registration number : NCT 00950326 Osteoarthritis (OA) is the most common and most enduring physical impairment of patients in the western world; age is known to be one of the most important risk factors for this disease.
Vulnerable groups – e.g. significant cognitive impairment, severe enduring mental illness, active malignancy or other terminal illness.
Schizophrenia results in enduring symptoms and prolonged functional impairment.
