A set of 74 functionally characterized lncRNAs show levels of diversity and divergence comparable to PC exons, suggesting that these lncRNAs are under substantial selective constraints.
Again, we mostly see lower values, indicating a substantial selective constraint in terms of the breadth, too.
Indeed, the Notch coactivator Mastermind, which is recruited by NICD and required for its activity (Wu et al. 2000; Fryer et al. 2002, 2004; Kovall 2007), has several pQ tracts that are under substantial selective constraint (Newfeld et al. 1991, 1993, 1994).
This might be caused by strong selective constraints (negative selection) at high temperature [ 19, 20].
It is assumed that homologous segments that show significant similarity are under strong selective constraints, while other sequences lacking similarity are evolving free from selective constraints.
In this case, as long as the data contains a substantial number of putatively neutrally evolving variants, a reasonably accurate estimate can be obtained, even in the presence of sites under strong selective constraints.
First, we observed that maternal genes were under less selective constraints while there were strong selective constraints effecting on earlier zygote-activated genes.
Essentially the same point has been made by reviewer 3. We now think that it is reasonable to treat a substantial positive correlation as "null-hypothesis", because it is expected in the simplest case of neutrality with some strong selective constraint.
The novel proteins exhibit significant selective constraint in the inferred reading frames, suggesting that many are functional.
An internally and externally cooled annular fuel was proposed for an advance PWR, which can endure substantial power uprating.
A common finding throughout the Canadian immigration literature is that, despite having high levels of education, recent immigrants endure substantial earnings disadvantages upon arrival that persist throughout their working career.
