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Considerably less evidence is available regarding cognitive dysfunctions as antecedents of AP, with preliminary indications that both the low and high ends of the functional distribution might be associated with later AP.
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The SPPB is a frequently used instrument that was shown to be valid not only in identifying and characterizing subjects at the disabled end of the functional spectrum but also in non-disabled, higher functioning older persons [ 39].
Genes with essential cellular functions would appear on the lower end of the functional impact score scale, while genes whose malfunction can be compensated for by diverse mechanisms or does not lead to very deleterious phenotypes are located at the upper end of the FIS scale.
The high-resolution anatomical scan was acquired on the same plane as the EPI data at the end of the functional runs using a 3D MPRAGE sequence (TE = 4 ms, flip angle = 8°, FOV = 300 ms 5/8, 160×256 matrix, 1.17×1.17×1.18 mm voxel size).
Here we investigated two prototypical Cav1.4 variants from either end of the functional spectrum.
At the end of the functional analysis, the MyHC isoform content of each fibre was also determined by SDS PAGE.
Through the Ncoef maps, the visual cortex was identified as the causal end of the functional network and the sensorimotor cortex as the caused end.
IL-2 secretion, in contrast, occupies the opposite end of the functional spectrum, requiring the highest amounts of antigen (Fig. 1B; 2K; 3K).
Therefore, the OA-FUNCTION-CAT might be of particular benefit in capturing change among symptomatic patients at either end of the functional difficulty or functional pain domains.
No intravenous sedative agent (e.g. propofol) was administered until the end of the functional mapping and resection of whole regions of the target, to avoid patient confusion.
In the remaining three patients, dyskinesias emerged after they had left the scanner room (i.e. after the end of the functional MRI experiment).
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