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Essential components of the DDR network, including ATM/ATR pathway, non-homologous ends joining (NHEJ) and homologous recombination (HR) repair, share homologues among almost all the eukaryotes [ 4].
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The Hohenzollern monarchy thus came to an end, joining those of the Habsburgs and the Romanovs.
non-homologous end joining breaks.
Microhomology-mediated end joining is also a mutagenic repair pathway.
Our data suggest that PLP1 deletions are likely caused by nonhomologous end joining.
DNA sequence analysis revealed that this deletion may be the result of microhomology-mediated end joining.
DSBs can be repaired by different repair mechanisms, including error-free homologous recombination (HR), potentially error-prone non-homologous end joining (NHEJ) and the highly mutagenic alternative end joining (alt-EJ) pathways.
Nonhomologous end joining (NHEJ) is a mechanism of DNA double-strand break repair in nearly all organisms and cell types.
In vivo, cells repair the DSBs through either non-homologous end joining (NHEJ) pathway or homologous recombination (HR) pathway.
The induced DSBs are repaired through more frequent nonhomologous end joining or less frequent homologous recombination, resulting in targeted mutations.
In recent years, another DSB repair pathway, namely, microhomology-mediated end joining (MMEJ), has received increasing attention.
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