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Iclaprim achieved non-inferiority compared with vancomycin for ECR at the ETP and secondary endpoints with a similar safety profile in two phase 3 studies for treatment of ABSSSI suspected or confirmed as caused by Gram-positive pathogens.
Also, the addition of the LTRA montelukast improves clinical endpoints, with a 56% increase in asthma-free days, for patients with persistent disease who were receiving ICS [ 56].
Time recording was done with both video and audio recording and by having the anesthesiologist mark the endpoints with a clear voice.
That meta-analysis did not include all currently available trials, however, and analysed only a restricted number of endpoints with a limited duration of follow-up.
47 In both studies, brimonidine tartrate 0.5% once daily showed significantly greater efficacy compared with vehicle for all efficacy endpoints, with a faster onset of action and a good safety and tolerability profile.
Missing data will not be imputed, and therefore, in case of incomplete cases, the sample size will differ between the secondary endpoints with a minimum of 10 participants in each treatment arm.
Similar(44)
For each RoF acceptance level, the experimentally determined primary drying endpoint was situated below the computed endpoint, with a certainty of 99%, ensuring sublimation was finished before secondary drying was started.
Assessment included patient-based evaluation of mouth dryness score (primary endpoint) with a visual analog scale (VAS), blinded assessment of the oral tissue condition by a four-point ordinal scale, and patient-based assessment of tolerability and acceptability.
Furthermore, a NMA was performed for each endpoint with a Bayesian framework using R 3.2.3 software.
Model coefficients were converted to an additive risk score for predicting the 7-day composite endpoint with a total point range of 0-100.
ORATORIO met its primary endpoint, with a statistically significant decrease in the percentage of patients with disability progression at 12 weeks at 32.9% with ocrelizumab vs.
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