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Endpoints were adjusted for gender, age, educational level, occupational level, physical activity, smoking status, alcohol drinking, and total energy intake.
The endpoints were adjusted for a CVP of 8 12 mmHg, a mean arterial pressure (MAP) >65 mmHg, and a urine output of at least 0.5 ml/kg/hour.
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When investigating the predictive effect of time to reach DSS 3, time to attain later endpoints was adjusted to the interval from DSS 3 in order to make parameters independent from each other.
Results for the NYHA endpoint are adjusted for baseline NYHA.
The primary endpoint was adjusted estimated GFR (eGFR; Cockcroft-Gault) at month 11 postrandomization.
For the malaria endpoint, estimates were adjusted for the effects of bednet usage defined as sleeping every night under an intact or impregnated net, recruitment centre and age.
To account for possible baseline imbalances, a secondary analysis will be performed in which comparison of treatment groups for all endpoints will be adjusted for predefined covariates using multiple regressions.
In this latter circumstance, there may be only one endpoint of interest in the clinical trial, but several competing endpoint analyses are available (e.g., an analysis of the endpoint that is adjusted for clinical center versus an analysis that is adjusted for geographic region versus an unadjusted analysis).
Thus, the overall sample size for the combined endpoint has been adjusted to take into account changes in the expected median OS for the control group.
Although these endpoints were not adjusted for multiple comparisons, NEPA300 was superior to PALO for no emesis, no significant nausea, and complete protection rates during all phases.
Duration of follow-up is adjusted to this endpoint en is relatively short to assess the safety of RRS with delayed RRO as it comes to cancer incidence and non-cancer related morbidity.
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