The aim of this work was to reach a consensus on the most appropriate endpoint to consider in future clinical trials evaluating the efficacy of antimicrobial treatment for HAP VAP, using Delphi method.
However, this possible excretion pathway does not exist for air breathing animals [91, 92] and therefore bioconcentration values in fish may not be the most relevant endpoint to consider.
Oral health-related quality of life (OHRQoL) is an important patient-centered endpoint to consider when assessing the impact of oral diseases in populations and evaluating the professional interventions used in attempt to improve oral health [ 1- 19].
However it was shown that firocoxib was able to slow down wound healing in a canine gastric mucosal injury model but by a mechanism independent of prostaglandin synthesis [ 8] meaning that a high COX-1/COX2 selectivity is not the only pharmacodynamic (PD) endpoint to consider when discussing NSAID g.i.t tolerability.
Because of their great experimental control over subjects, exposures, and endpoints, toxicologists tend to consider a wider range of toxic interactions among mixture components and sequential exposures than is practical for human studies.
In the sense of the presented test strategy, most important endpoints to be considered include further (a) biotic transformation/degradation, mobility and transport in porous media, and sorption to soil, sediment and sludge of the pristine and aged ENM.
Among the outcome measures (endpoints) to be considered in SLE trials are biomarker manifestations (for example, anti-dsDNA Abs).
Study endpoints were rare enough to consider the exposure odds ratio to be a reasonable estimate of relative risk.
In addition, when evaluating the efficacy of environmental interventions, numerous health endpoints may be valuable to consider.
