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Further research should include multicenter studies with clinical endpoints to confirm our results.
A large prospective multicenter study with renal impairment as one of the primary defined endpoints to confirm whether sedation causes renal impairment is now warranted.
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PCR was chosen as the primary endpoint to confirm non-inferiority regarding the comparative efficacy with the standard chemoradiation option for these patients as this will then allow more confident treatment decisions to exclude radiotherapy for such patients in the future.
At the baseline visit, which was defined as week 0 and followed the run-in period, patients returned to the study site to complete the randomisation procedures (assessment of pulmonary function and general asthma symptom-based endpoints) and to confirm that randomisation criteria were met.
This underlines the need for an RCT with sufficient power and clinically relevant endpoints to either confirm or refute the possible negative effects of older RBCs transfused to critically ill patients.
A larger study with functional endpoints is needed to confirm our findings.
A head-to-head study incorporating clinical endpoints would be required to confirm whether the observed differences in immune response between the vaccines influence the duration of protection they provided.
As an immune correlate of protection has not yet been defined, a head-to-head study incorporating clinical endpoints would be required to confirm whether the observed differences in immune response between the vaccines influence the duration of protection they provide.
Other endpoints which are often used include arrhythmias, LV geometry and function, and so forth, all of which are surrogate endpoints that can be used to confirm cardioprotection.
The distribution of baseline QUALIOST® scores is provided in Table 2. Baseline scores based on number of fractures occurring between baseline and endpoint It is usually recommended to confirm the psychometric properties of an instrument whenever it is used in a new population [ 15].
Thus parallel analysis of categorised and continuous endpoints was used as supportive approach to confirm congruent results.
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