Exact(15)
Cantor had shown that every linearly ordered set $S$ without endpoints that is dense (i.e., between any two different elements of $S$ there is another one), complete (i.e., every subset of $S$ that is bounded above has a supremum), and with a countable dense subset is isomorphic to the real line.
Here we show that the stereotyped durations and trajectories are optimal for minimizing the variability in saccade endpoints that is caused by motor noise.
There is a problem of proof related to the choice of endpoints that is difficult to handle.
6 9 Considering three primary endpoints, that is with the exclusion of the duration of effect criterion, approximately 60% of patients achieved response.
They concluded this, in part, by studying what happens when clinical trials do not use mortality to establish effectiveness, but instead use "surrogate endpoints" — that is, biomarkers that stand as proxies for eventual outcomes and help estimate how effective the drugs will be.
We denote as the segment as shown in Figure 3. Now, we use to denote the set of all perimeter segments formed by consecutive endpoints, that is,.
Similar(45)
This article will discuss a number of surrogate endpoints that are likely candidates to serve this role.
It is therefore of utmost importance to identify appropriate surrogate endpoints that are reasonably likely to measure true clinical benefit.
The study designs are described in sufficient detail to allow the reader to grasp the endpoints that are typically included in these designs along with some alternative approaches and optional endpoints that can be included in these designs.
Other studies may use endpoints that are rare enough to require the irradiation of hundreds of thousands of cells in order to observe and quantify the effects.
These data identify multiple noncanonical endpoints that are pivotal for rational design of hedgehog modulators and provide a new therapeutic avenue for obesity and diabetes.
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