Norepinephrine was used in a stepwise manner to achieve predefined endpoints: mean arterial pressure (MAP) ≥65 mmHg and urine output ≥0.5 mL/kg/h.
Among the 66 pivotal studies in the summaries, 120 primary endpoints (mean 1.8 per pivotal study) were found, while none could be identified in seven (11%) studies.
For prespecified primary and secondary endpoints, mean stool frequency and rectal bleeding scores were derived from values recorded in the 7 days prior to the study visit.
As seen with the clinical efficacy endpoints, mean improvements in axSpA signs and symptoms increased further from weeks 8 to 16, with the most pronounced improvements in the placebo/etanercept group.
Descriptive statistics for change in endpoints (mean, median, and standard deviation) between baseline and 12-week measurements will be computed separately for each program format (face-to-face or hybrid mobile technology-supported program).
Snowden's follow-on sentence is equally important: "Unfortunately, endpoint security is so terrifically weak that NSA can frequently find ways around it". Endpoint means the software you're using, the computer you're using it on, and the local network you're using it in.
For pairwise comparisons of endpoint means of experimental and control groups, two-tailed t tests were conducted using Prism (GraphPad).
The absolute change from baseline to endpoint means the baseline value is subtracted from the endpoint value.
The use of RT-PCR-confirmed infection as the endpoint means the potential for under-ascertainment, if some infections were not virologically confirmed.
Although the primary analyses proposed a full information mixed model approach, to be conservative, the power calculations were also examined based on a two-group comparison of endpoint means (differences in means), with possible attrition.
