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The different sensitivities of the endpoints may reflect the diversity of the microflora responsible for the different activities and hence their potential for recovery.
The considerations of patient and clinical endpoints in addition to plan endpoints may reflect an evolution of drug management program evaluations.
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Heightened symptoms for the non-taxane group were not observed for other PCM endpoints, and may reflect selection of patients with existing performance impairment into non-taxane treatment regimens.
Home-time represents a novel, easily measured, patient-centered endpoint that may reflect effectiveness of interventions in future HF studies.
Therefore, they argue that the studies in which LOS and convalescence were utilized as endpoints may merely reflect traditions of perioperative care associated with open procedures rather than differences between open and closed surgical techniques.
Molecular endpoints such as gene expression that may reflect phenotypic disease symptoms manifested later at higher biological levels (e.g., cell, tissue, organ, or organism) are potentially biomarkers that meet such demands.
The 2 endpoints of infection in our study may reflect different types of infections, or at least different stages of infection.
Behavioral responses (e.g., voice onset times or button press latencies) are less suited; as they record the endpoint of a complex chain of processes, they may reflect not only processes of interest (e.g., semantic access) but also processes related to decision-making and response preparation.
One can argue that CIN3+ as endpoint should be preferred for CIN2+ as higher CIN2+ rates may reflect mostly self-limiting lesions.
Measurement of biomarkers in CSF may reflect accurately the status of ICH and serve as surrogate endpoints for experimental or nonoptimized therapies; some of these may be used in the early identification and diagnosis of the condition and its sequelae, as well as for determining the prognosis [ 31].
While serum markers may reflect clinical outcome, their clinical importance as an appropriate endpoint remains open to debate [ 88].
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