Sentence examples for endpoints may be from inspiring English sources

If data on patient-relevant endpoints are not available, surrogate endpoints may be used (Section 4.5.3 Suppl. G-BA VerfO).

Both types of trial record the occurrence of seizures over a set period from which a large number of endpoints may be derived for analysis.

In randomized controlled trials, two endpoints may be necessary to capture the multidimensional concept of the intervention and the objectives of the study adequately.

Furthermore, test statistics should be invariant under scale transformations of the data, since the endpoints may be measured on different scales.

In comparison with G-BA/IQWiG, however, NICE appears to generally assume a less restrictive position: Surrogate endpoints may be accepted more readily - provided they are reasonably likely to predict clinical benefit - since full validation may be postponed.

Programme effects span levels and other boundaries within a system, vary dynamically or are cumulative over time and are problematic to understand in terms of cause and effect, where concurrent external influences exist and the impact upon study endpoints may be mediated by a range of organisational and social factors.

This suggestion holds in particular when the variability of the endpoint may be influenced by the amendment.

Alternatively, two inversions with one shared endpoint may be responsible or two inversions with unique endpoints followed by a transposition can explain the differences.

A difference of at least 3 standard errors in the interim analysis of a major endpoint may be needed to justify halting, or modifying, such a study prematurely.

8– 10 However, SREs as a composite endpoint may be underestimated compared to other studies 9, 10 because hypercalcemia of malignancy was not included in our definition of SRE.

A difference of at least three standard deviations in the interim analysis of a major endpoint may be needed to justify halting, or modifying, such a study prematurely.