The most sensitive toxicological endpoint in the development of the embryos was failure to hatch, which had an EC50 of 0.19 mg HCO1 l−1.
The use of patient-reported outcomes as a secondary endpoint in the development of new antidepressants has been of growing interest in recent years.
Plasma oestradiol analysis has also provided a key pharmacodynamic endpoint in the development of inhibitors of aromatase, the enzyme responsible for oestrogen synthesis [ 1].
Therefore, it seems logical to deprioritise the development of new in vitro methods to predict iritis as well as the use of this endpoint as reference in the development of in vitro testing strategies.
Due to the long natural history of the disease, the improvement in hard endpoints [e.g., reduction in the development of liver-related outcomes (cirrhosis, variceal bleeds, ascites, hepatocellular carcinoma) and mortality] may not be feasible in a 2-year pivotal trial.
Given the greater potential for misspecification that arises from the consideration of economic and clinical endpoints in the analysis, the development of such approaches for evaluating cost-effectiveness and their comparison with standalone solutions is highly desirable.
In addition, if signaling through the progesterone receptor is involved in the development of endpoints that are thought to be androgen-mediated, the increase in progesterone receptor in females may provide more opportunity for the development of these ostensibly androgen-associated phenotypes.
There is a consensus that IAUGC60 and Ktrans should be used as quantitative endpoints for DCE-MRI when used in the development of anti-angiogenic and anti-vascular agents [ 33, 34], with a recent report on DCE-MRI quantification supporting a CV of less than 20%% for these parameters [ 35].
The primary endpoint was the development of lung injury in each study group.
We have found that the receptor of IL-8 (CXCL2) is involved in atherogenesis induced by environmental pollutants, such as dioxin [ 25], indicating the importance of IL-8 in the development of pathological endpoints.
