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While overall survival is generally the most well-established outcome of oncologic clinical trials, time to progression, progression-free survival, and progression-free survival at 6 months are becoming more reasonable endpoints in evaluating brain tumor response [ 7, 28, 29].
Based on therapy resistance and increasing evidence supporting the cancer stem cell (CSC) hypothesis [ 38- 40], tumor recurrence after treatment cessation and functional CSC assays can also be critical endpoints in evaluating treatment response to targeted therapies.
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These data argue that radial arm water maze testing of doubly transgenic mice may be a useful behavioral endpoint in evaluating the functional consequences of potential AD therapies, especially those designed to reduce Aβ load.
When considering well-established dosimetric endpoints used in evaluating treatment plans, BED-DVH's for the rectum and bladder correlate better with late toxicity than C-DVH's and should be considered when attempting to minimize late GI and GU toxicity after external beam radiotherapy for prostate cancer.
The main objective of this study was to investigate the value of multiple endpoint measurements in evaluating the cytotoxicity of three divalent zinc salts in three established fish cell lines (EPC, CHSE and RTG-2) and the potential for their employment as effective screening tools for zinc contaminated environmental samples.
Analysis by number of endpoints included in the studies in each drug management tool category (n = 76) The predominant study endpoint category utilized in evaluating the impact of drug management program tools was plan focused (53/76 studies, 68%; Table 3).
The fertility study design recommended in the ICH S5 R2) Harmonised Guideline for Detection of Toxicity to Reproduction for Medicinal Products emphasizes the importance of histopathological endpoints next to a pairing assessment in evaluating male fertility.
Evaluation of acute aquatic toxicity endpoints is a critical first step in evaluating the aquatic hazards of PSOA for risk assessment given its primary mode of disposal.
The findings of our study complement the theme of 3Rs, providing promising and time-saving alternatives to animal trials in evaluating different toxicological endpoints for newly synthesized chemical structures.
Disease-specific symptom assessment has potential to play a key role in evaluating patient-related endpoints in clinical trials.
However, in spite of the importance of sleep disturbances on patients' well-being, to date nighttime awakenings have been infrequently studied as an endpoint in trials evaluating COPD treatments [ 6- 10].
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