Sentence examples for endpoint use from inspiring English sources

This review highlights the regulatory paths and considerations for developing DDTs required to advance biomarker and endpoint use in clinical development (e.g., consensus CDISC [Clinical Data Interchange Standards Consortium] data standards, precompetitive sharing of anonymized patient-level data, and continual alignment with regulators).

More specifically, interventional trials should be adequately powered for a clinical endpoint, use a sound adherence measure, and be statistically robust.

Drugs granted orphan drug designations at the time of original approval had the same rates of active comparator and clinical endpoint use in subsequently approved indications, even when such supplemental indications were for non-rare conditions.

Although the incidence rate of CRC would be the most reliable endpoint, use of this endpoint would be unsuitable for chemoprevention trials, because of the relatively low occurrence rate of CRC in the general population [ 22] and the long-term observation period that it would necessitate.

Although the incidence rate of CRC would be the most reliable endpoint, use of this endpoint would be unsuitable for chemoprevention trials, because of the relatively low occurrence rate of CRC in the general population and the long-term observation period that it would necessitate.

Clinical trials are designed to address the primary endpoint using prespecified α and power levels.

We model the distribution of this bivariate binary endpoint using the bivariate probit model.

We model the distribution of this bivariate binary endpoint using either Gumbel bivariate logistic regression or Cox bivariate binary model.

Severity of TD was evaluated at the baseline and endpoint, using the Abnormal Involuntary Movement Scale (AIMS).

Viral cytopathic effects were monitored over a period of 3 7 days and a virus titre was calculated by determining the 50% endpoint using the formula of Reed and Muench43.

If the endpoint uses SMBv1, a vulnerability7 is exploited and the endpoint is also infected.