Secondary endpoint: requirement of renal replacement therapy (RRT).
Composite primary endpoint: requirement of renal replacement therapy (RRT), death, persistent increase in creatinine ≥ 0.3 mg/dl as compared with baseline value.
In fact, many of the current environmental programs such as the European Water Framework Directive (WFD) or the US Clean Water Act do not explicitly test for EDCs, and considering the unique requirements and endpoints required to assess the endocrine potential of a sample, these programs are unlikely to appropriately address exposure to these chemicals.
For example, programs such as the European WFD (EC 2000/60/EG) or the US Clean Water Act do not explicitly test for EDCs, and considering the unique requirements and endpoints required to assess the endocrine potential of a sample, these programs are unlikely to appropriately address exposure to these chemicals.
Moreover, programs such as the European WFD or the US Clean Water Act do not explicitly test for EDCs, and considering the unique requirements and endpoints required to assess the endocrine potential of a sample, these programs are unlikely to appropriately address exposure to these chemicals.
This study failed to show any effect on the primary endpoint, RBC transfusion requirements, between placebo-treated and rFVIIa-treated patients.
Within this subgroup, it was shown that treatment with rFVIIa was particularly beneficial in effecting a reduction in the primary clinical endpoint of RBC requirements during 48 hours (Table 4).
Adults and children have to present: The same disease progression Similar PKPD relationships Similar endpoints The same disease progression Similar PKPD relationships Similar endpoints If these requirements are not met, further PKPD or efficacy studies are needed.
Secondary endpoints included transfusion requirements, time to chest tube removal, time to extubation and length of ICU and hospital stay.
b) An unexpectedly high number of patients were not evaluable for primary endpoint according to the requirements specified in and implied by the protocol.
