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Mice were sacrificed at a defined endpoint of two weeks post diagnosis.
Historically, the criterion for achieving this approval is to meet the primary endpoint of two independent double-blind, placebo-controlled phase III trials.
In total, 33 (94 %) of the 35 patients achieved the primary endpoint of two consecutive visits with a platelet count ≥70 × 10/L.
HRQoL, assessed using the HAEMO-QOL set of questionnaires, was a secondary endpoint of two phase 3 multinational clinical trials, guardian™ 1 and 3 15, 15.
Lung injury score, wet/dry ratio, arterial oxygen tension, oxidative injury, and expression of pro-inflammatory mediators and apoptotic genes were assessed at the endpoint of two hours using the high-tidal volume protocol.
When the analysis was conducted for the more rigorous endpoint of two grades or more improvement (ie, improving to 0 ["no wrinkle"] or 1 ["shallow, just perceptible wrinkle"] on the NLF severity scale at day 3), the physicians and subjects also rated the treatments similarly at this clinic visit.
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Whenever two unknown quantities are found in final equality, there results a locus fixed in place, and the endpoint of one of these unknown quantities describes a straight line or a curve.
By means of this construction Fermat was able to formulate the fundamental principle of analytic geometry: Whenever two unknown quantities are found in final equality, there results a locus fixed in place, and the endpoint of one of these unknown quantities describes a straight line or a curve.
All of the ΔLF/EF-infected mice and approximately 10% of the Sterne-infected mice survived until the experimental endpoint of three weeks (Fig. 7A).
All PBSC collections had an endpoint of five hours processing time.
Gas exchange and apoptosis were assessed at the endpoint of five hours using the low-tidal volume protocol.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com