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Importantly, the key endpoint of the model, AP-1 formation, is very reproducible across all treatment conditions.
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AIDS and death are endpoints of the model.
The primary endpoints of the model were life-years gained, quality-adjusted life-years (QALYs), and incremental cost-effectiveness ratios for denosumab against the comparators.
The primary endpoints of the model were life-years gained, quality-adjusted life-years (QALYs), and incremental cost-effectiveness ratios (ICERs) for denosumab against the comparators.
The first model was used to identify determinants of health insurance enrolment and thereby enable adjustment for possible confounding in the main analysis, so the endpoint of the first model was enrolment into CBHI and age at first enrolment was used as the time variable.
Due to the main interests of this study and the certainty of data sources, cervical cancer incidence and mortality were chosen as primary endpoints for the model calibration process of matching the outputs in the current practice arm without vaccination of the model to observed cancer statistics.
The establishment of anhedonia (lack of pleasure) is one of the major validated endpoints in the model of depression using rodents [2].
The primary endpoint of our model was advanced neoplasia located anywhere in the colorectum, therefore, the risk score is not optimised for sigmoidoscopy screening.
The weighting factor should be used to discriminate the importance of the measurement endpoints during the application of the model should this information be available.
We carried out Monte Carlo simulations, with 1,000,000 computations of the model endpoints, each time with a set of parameters sampled in a rectangular distribution within the proposed ranges.
Additionally, the endpoint values and the prediction results of the model are employed within the visualization.
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