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Snowden's follow-on sentence is equally important: "Unfortunately, endpoint security is so terrifically weak that NSA can frequently find ways around it". Endpoint means the software you're using, the computer you're using it on, and the local network you're using it in.
For pairwise comparisons of endpoint means of experimental and control groups, two-tailed t tests were conducted using Prism (GraphPad).
The absolute change from baseline to endpoint means the baseline value is subtracted from the endpoint value.
The use of RT-PCR-confirmed infection as the endpoint means the potential for under-ascertainment, if some infections were not virologically confirmed.
Although the primary analyses proposed a full information mixed model approach, to be conservative, the power calculations were also examined based on a two-group comparison of endpoint means (differences in means), with possible attrition.
Although power is greater for evaluation of slopes over endpoint means, it is not recommended that sample sizes be less than 80, given that the power calculations in the REACH project also yielded requirements in the range of 80−100 per group.
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Three statistics are investigated to detect the endpoint, mean, SD and CV.
Endpoint mean pain scores were significantly reduced in patients receiving 150 or 300 mg/day pregabalin compared with placebo.
For the primary endpoint, mean and standard deviation (SD) of reduction in headache frequency were 4.6 (1.9) for those in polytherapy, relative to 3.5 (2.3) for those in monotherapy.
The primary efficacy endpoint, mean change from baseline (28-day pre-treatment period) to 12-week randomization period in monthly average number of migraine days was analyzed using an analysis of covariance method or the Wilcoxon rank sum test.
The primary efficacy endpoint, mean change from baseline (28-day pre-treatment period) to 12-week randomization period in monthly average number of headache days was analyzed using an analysis of covariance method or the Wilcoxon rank sum test.
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