Exact(2)
Based on the concept of the gH-derivative, Stefanini et al. developed the relationship between gH-derivative and conventional derivatives, in other words, the gH-derivative of f can be expressed by the derivatives of its endpoint functions.
Assume that the endpoint functions (underline{u}(x;r)) and (bar{u}(x;r)) are both Riemann-integrable on ([a,infty]) for every (bgeq a), and assume that there are two positive (underline{M}(r)) and (bar{M}(r)) such that (int_{a}^{b}|underline{u}(x;r)|, mathrm{d}x lequnderline{M}(r)) and (int_{a}^{b}|bar{u}(x;r)|, mathrm{d}x leqbar{M}(r)) for every (bgeq a).
Similar(58)
Synthetic lethal interactions can reflect, for instance, non-essential elements of compensatory pathways that converge on the same essential endpoint function.
Most pronounced effects are generally observed after prolonged exposures (e.g. 96 h exposure for algae and daphnids); and for endpoints assessing functions (growth, mobility, reproduction) rather than mortality.
Endpoint cardiac function was assessed by echocardiography and catheterization.
From baseline to the 12-week endpoint, physical function decreased by 17% (7.7 mm [CI: -0.3, 15.8]) in the MSM group and increased by 15% (6.9 mm [CI: 0.1, 13.9]) in the placebo group, corresponding to a difference of 14.6 mm [CI: 4.3, 25.0] between groups (p = 0.04).
The results from the latest trials, in 2014, focused on three endpoints: sexual function index (where women answered questions about sexual experience and rated levels of sexual desire on a scale of one to five over the last 28 days), satisfied sexual events, and distress felt from a low libido.
In general, results of randomized controlled trials (RCTs) of RA report clinical endpoints, physical function and HRQoL independently when evaluating treatment efficacy.
Although our present study was focused on kidney function as a primary endpoint, perioperative kidney function is a very relevant parameter in predicting long-term outcomes [ 41- 43].
Figure 7A illustrates the magnitude portion of typical endpoint impedance transfer functions.
The primary endpoint regarding erectile function was the difference in median IIEF-5 score between the groups.
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