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Understanding the development of parasite growth inhibition within the context of natural malaria infection and transmission is essential to blood stage vaccine endpoint evaluation.
It is possible that growth inhibitory antibodies have a more important function in children than adults, an important consideration in blood stage vaccine endpoint evaluation.
During the primary phase of the study, i.e. up to month 10, the study was partially blinded, whereby investigators involved in endpoint evaluation and parents/guardians were blinded to the vaccine administered, but not to the schedule.
‡PROBE (Prospective, Randomized, Open with Blinded Endpoint evaluation) design trials.
Power calculation was conducted for gastric emptying Thalf the primary endpoint evaluation.
A total of 229 patients were available for primary endpoint evaluation (modified intention to treat population).
Similar(29)
The combination product demonstrated numerically greater improvements for a number of the secondary endpoint evaluations versus all three of the comparators, with many endpoints meeting the criteria for statistical significance as per the sequential gatekeeping approach.
IMPACT 2002+ methodology is selected to perform the impact assessment within the SC since it proposes a feasible implementation of a combined midpoint-endpoint evaluation.
This study was a single-center study with a prospective, randomized, open, blinded-endpoint evaluation (PROBE) design in type 2 diabetic patients being treated on an outpatient basis at our clinic, who ranged in age between 20 years of age or older but younger than 80 years old, and who had secondary failure.
In this study, MIC was performed using 96-well microtitre plate and data were collected by means of a spectrophotometric endpoints evaluation.
The primary endpoint for evaluation of efficacy was change in total IPSS from baseline; secondary endpoints were change in Qmax and evaluation of subjective symptoms, eg, IPSS voiding and storage scores and quality of life score.
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