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Overall baseline to endpoint changes in weight was not statistically significant between groups.
As a secondary endpoint, changes in ER expression will be measured using serial FES-PET imaging.
It is important to highlight that two processes, excess β-amyloid deposition and tau hyperphosphylation, contribute to these endpoint changes.
As mentioned earlier, the distribution of this endpoint changes over time in accordance with the kinetics of the cell population.
This may mean the study was underpowered to detect endpoint changes in secondary outcomes, such as the severity of depression.
However, in this study, we used a sensitive scale (MADRS) to detect endpoint changes in depression symptoms in response to the treatment of depression [ 45].
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As a secondary endpoint, change in HIT-6 score was evaluated from baseline to 4 weeks after administration of the last dose of study drug.
The endpoint change wouldn't have mattered ENHANCE showed no benefit for Vytorin over Zocor in any set of artery images.
Primary endpoint: Change of glycemic control (hemoglobin A1C).
The study was powered against the primary endpoint change in HbA1c.
Response criteria: a statistically significant baseline to endpoint change in HAM-D.
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CEO of Professional Science Editing for Scientists @ prosciediting.com