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We performed pair-wise correlation coefficient analysis and identified strong correlations between the endogenous variations in the miRNA and mRNA expression.
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Several normalization techniques have been used to minimize effects of this high within-treatment endogenous variation.
High endogenous variation within a condition can obscure between-condition changes.
If endogenous variation causes all compounds to vary as a simple multiple of the TA, then expressing each compound amount as a proportion of the TA for the sample is an unbiased estimator of relative abundances (RA).
The intuition is that taking twin or sibling differences filters out some, but not all, endogenous variation but also filters out exogenous variation.
8-OHdG exhibits a large degree of intra-individual variability indicating a large endogenous variation of oxidative DNA damage [ 37, 38].
Month-to-month change in cholinesterase was included as farmworkers' endogenous variation in cholinesterase to more clearly delineate the potential effects of pesticide exposure.
To argue that the within-sibling estimator is more consistent than the between-sibling estimator, this endogenous variation as a share of the total variation should be less in the within than the between-sibling estimation.
There is no reason to be confident that this is the case, as the within-sibling analysis also removes exogenous variation, which – together with the endogenous variation – determines the inconsistency (Bound and Solon, 1999).
For example, some potentially endogenous variation that may remain in a within-sibling estimation are unobserved differences between siblings in nutrition and physical activity, both of which affect growth and final attained height.
In contrast under competitive conditions, there were no statistical differences observed for vegetative biomass or seed yield for any of the hybrid lines, but there was a great deal of endogenous variation among data in the competition experiment.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com