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Several normalization techniques have been used to minimize effects of this high within-treatment endogenous variation.
High endogenous variation within a condition can obscure between-condition changes.
If endogenous variation causes all compounds to vary as a simple multiple of the TA, then expressing each compound amount as a proportion of the TA for the sample is an unbiased estimator of relative abundances (RA).
The intuition is that taking twin or sibling differences filters out some, but not all, endogenous variation but also filters out exogenous variation.
8-OHdG exhibits a large degree of intra-individual variability indicating a large endogenous variation of oxidative DNA damage [ 37, 38].
Month-to-month change in cholinesterase was included as farmworkers' endogenous variation in cholinesterase to more clearly delineate the potential effects of pesticide exposure.
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We performed pair-wise correlation coefficient analysis and identified strong correlations between the endogenous variations in the miRNA and mRNA expression.
PRA was measured both by a conventional method and by a new high-sensitivity assay (hs-PRA), which is independent of endogenous substrate variation (21).
Endogenous metabolite variations induced by BPA exposure (25 µg) in PND2 pups (whole body samples) showed increases in lactate, glucose, cholines, creatine, and glycine compared with control samples.
The goal of this study is to create and characterize a murine model of septic cachexia and evaluate endogenous ghrelin variations.
We calculated all EACs of the considered enzymes and multiplied them to their corresponding rate equations to reflect endogenous activity variations.
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