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As a result, our data provided no evidence of endogenous transportation to TH centers (see Tables, Additional file 1, for full stage 1 and stage 2 estimation results).
Nevertheless, the data showed no evidence of endogenous transportation to TH centers related to in-hospital survival (Z = -0.08, p = 0.934) or 30-day survival (Z = 0.94, p = 0.349).
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Hence, exogenous small RNAs have also been transferred by exosomes by mimicking the molecular mechanism of endogenous miRNAs transportation.
These findings suggest that crucial endogenous protein regulatory mechanisms govern the transportation and assembly of virally expressed proteins.
Serum albumins are the most abundant carrier proteins in blood plasma and participate in the binding and transportation of various exogenous and endogenous compounds in the body.
The transportation and distribution of many endogenous substrates like hormones, bile acids and neurotransmitters mainly depend on the activity of transporters.
As mentioned above, patient transportation to TH centers is potentially endogenous, since prehospital EMS personnel may exercise discretion in their choice of destination hospital.
In plants, jasmonate (JA) is not only a key endogenous plant hormone but also a long-distance transportation wound signal molecule that participates in plant defense responses 8, 9, 10, 11, 12, 13, 14.
Our finding that transportation to a TH center is not endogenous suggests that local EMS units do not alter the transport destination of OHCA patients on the basis of survival probability or likely benefit from care at a TH center.
However, overexpression of ABCG2 decreased the endogenous level of PPIX suggesting ABCG2 might play a role in transportation of cytosolic porphyrins (Fig. 5A).
This protection compensates for the loss of cytoplasmic sperm enzymes that occurs during maturation and transportation processes, resulting in diminution of the spermatozoa's endogenous enzymatic and repair defenses [ 4– 7].
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