Exact(4)
Precisely manipulating the genome of mammals by introducing or deleting genes gives a unique understanding into how these genes functionally integrate into biology in their endogenous setting.
To confirm that the NKX2-5 EmGFP reporter localized expression of NKX2-5 in an endogenous setting, we created chimeric mice from the NKX2.5 marked ES cells with an eight-cell laser-assisted tochnique to maximize embryo chimerism [27], [28].
To exclude the possibility that apparent dimers were a consequence of heterologous overexpression, we asked whether dimers would be observed in an endogenous setting.
Although transgene assays have argued that the activity of an insulator depends upon its neighbors (for review see [ 1]), this would be one of the first examples in an endogenous setting.
Similar(56)
In other gene families in the "endogenous set", defining relationships between human CYPs with important endogenous functions and the zebrafish homologs is complicated by the presence of multiple closely related paralogs in zebrafish, not found in human.
This paper uses an endogenous choice set model to investigate the influence that contextual effects and socioeconomic characteristics play in explaining variations in the choice sets considered by respondents when they reveal their preferences.
While the observer can implement an endogenous task set to look for information in a certain manner, the saliency of stimulation will also guide the search [35].
As a consequence, two calibration curves, transgenic and endogenous, were set up for each DNA calibrator of this relative quantification.
Moreover, adiponectin-depleted fibroblasts were hypersensitive to TGF-β treatment, with significantly enhanced stimulation of collagen and α-SMA gene expression compared to fibroblasts transfected with control siRNA, suggesting an inhibitory function for endogenous adiponectin in setting the intensity of TGF-β signaling.
This paper studies optimal auction design in a private value setting with endogenous information gathering.
Using a two-sector overlapping generations setting with endogenous growth driven by human capital accumulation, we prove that relative factor intensity between sectors drastically shapes the welfare analysis: two identical laissez-faire economies with different sectoral capital shares may generate physical capital excess or scarcity, with respect to the optimum.
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