Sentence examples for endogenous resolution from inspiring English sources

Identification of these pathways will improve understanding of the capacity of tissues to terminate inflammatory responses and contribute to the development of therapeutic strategies based on endogenous resolution.

However, they may also prolong posttreatment pain by disrupting endogenous resolution circuits [ 47].

In fact, COX-2 inhibitors are able to disrupt endogenous resolution mechanisms.

As a result, we propose that this self-limiting model (induced by 0.1 mg zymosan) be used to identify novel endogenous resolution pathways that may be dysregulated or absent in the delayed or nonresolving inflammation.

Collectively, these findings indicate that microparticle-A2MG activated endogenous host protective mechanisms that assure an efficient leukocytic response, mainly involving neutrophils and possibly macrophages, with effective clearance of the pathogen and the timely and efficient onset of resolution, with selective engagement of endogenous resolution pathways, leading to increased survival.

Rather than inhibiting molecular events that occur at the beginning of the immune response, a process that may thwart the body's own attempt to heal, our study now proposes a new approach for taming inflammation by directly stimulating endogenous resolution mechanisms; the induction of SPMs via the activation of the TLR7 pathway.

We believe these new data raise the profile of AnxA1 from being solely a short-term anti-inflammatory factor, to being a 'trigger' of the endogenous pro-resolution arsenal.

54 Zebrafish are also beginning to offer clues to the endogenous mechanisms for resolution of inflammation.

In this technique, following immunofluorescent intracellular staining of endogenous LC3, high-resolution images of >100 000 individual cells in flow were captured and the number of LC3+ positive punctae (spot count) were calculated, following background subtraction.

Hence, it is important to achieve a more complete understanding of the local cellular and molecular events that govern the formation and actions of local mediators that can serve as endogenous local mediators of resolution.

This may suggest that FAN1 does not function with FA proteins in the resolution of endogenous replication obstacles.