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As targeting of antigen to immature DCs in vivo has been shown to induce T cell tolerance [55], [56], [57], our results underscore the utility of providing a stimulus for endogenous resident DCs in DC vaccination protocols.
This finding suggests paracrine signalling between exogenously delivered cells and endogenous resident progenitors.
Endogenous resident MSCs have been shown to play important roles in local repair in the kidney, including maintaining the endothelium stabilized.
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We then tested whether the two recombinant forms of ERβ were able to interfere with target gene activation by the endogenous ERα resident in MCF-7 cells.
On the other hand, activation or stimulation of endogenous or resident stem cells is another strategy to abate aging and age-associated disease.
Here we show that specific CD8+ T cell responses induced in response to intravenous administration of antigen-loaded bone marrow-derived dendritic cells (BM-DCs), were ablated in mice selectively depleted of endogenous lymphoid-resident langerin+ CD8α+ dendritic cells (DCs), suggesting that the antigen is transferred from the injected cells to resident APCs.
In this report we investigated the contribution of endogenous lymphoid-resident DCs to T cell priming after vaccination with antigen-loaded BM-DCs.
The purity of PM fractions was checked by assessing the enrichment of the endogenous PM-resident protein PMA2.
Most importantly, the tagged version of CaNDR1a was significantly enriched in PM fractions compared to microsomal ones, as also observed for the endogenous PM-resident protein PMA2.
An endogenous raft-resident Akt has been reported in LNCaP human prostate cells that showed a different substrate affinity as compared with non-raft Akt, suggesting the presence of distinct Akt populations with differential signaling behavior.
However, whether these neo-cardiomyocytes are derived from endogenous population of resident cardiac stem cells or from the exogenous double assurance population of resident bone marrow-derived stem cells that populate the damaged myocardium is unresolved and under intense investigation.
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