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In the original ANT, the 100% valid cue condition induced an impure, mixed exogenous and endogenous orientation of attention (exogenous attention raised by the cue presentation, and endogenous attention raised by the always predictive meaning of the cue).
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In support of this view, ectopic expression of Insc in epithelial cells is sufficient to override the endogenous planar spindle orientation and to re-orient the spindle in the apical-basal axis [ 28].
Four alternative contexts are described: endogenous renewal; re-orientation of trajectories; emergent transformation and purposive transitions.
The distribution of integration sites potentially could be used for identification of active promoters or transcribed units as illustrated by analysis of the transcribed fraction of the human genome using orientation of endogenous transposons [ 2].
A population of the talitrid amphipod Talitrus saltator (Montagu, 1808) was investigated on an exposed sandy beach on the Atlantic coast of Portugal (Leirosa beach) to estimate orientation capabilities and endogenous rhythms in conditions of recent changes in the landscape (artificial reconstruction of the foredune) and beach morphodynamics (stabilization against erosion from the sea).
The expression level is lower when the transgene is adjacent to, and in the same orientation as, the endogenous promoter.
(CTG 240.4 insertion lies within the first intron of the CG9650 gene that encodes a zinc finger protein [20], [21], in the same orientation as the endogenous transcription unit (Figure 6A).
Although there is some evidence that juveniles can compensate for previously experienced drift (Evans 1968; Fitzgerald and Taylor 2008; Thorup et al. 2011), most evidence points to endogenous control being paramount to orientation among juvenile migrants (Perdeck 1958; Thorup et al. 2007a; Wiltschko and Wiltschko 2009).
Thus, endogenous PC1 can assume a transmembrane orientation in situ in AtT20 cells.
After PCR screening, 60/93 of the tested MiMICs allowed integration of at least one donor in the proper orientation to tag the endogenous gene (Supplementary file 1).
The hypothesis pursued in the present study has been that bone formation by AMOR is attributable to the ability of anti-BMP-2 mAbs to capture and tether endogenous BMP-2 in a biologically active orientation.
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