Sentence examples for endogenous obstacles from inspiring English sources

These studies indicate that shelterin proteins together with telomerase or accessory proteins, such as WRN, are required to prevent telomere abnormalities resulting from endogenous obstacles to telomeric replication.

Similar Endogenous obstacles were described by women who had been incentivised for cessation and those who had not.

It is clear that studies of the rare genetic disease Fanconi anaemia have provided and will continue to provide important knowledge on how cells respond to endogenous replication obstacles, on the nature of these obstacles and on how cells can surmount chemotherapeutic treatments that cause replication failure.

This may suggest that FAN1 does not function with FA proteins in the resolution of endogenous replication obstacles.

This high rate of repair using endogenous sequences presents obvious obstacles to gene therapy strategies using CRISPR/Cas9, as pseudogenes and paralogs may effectively compete with exogenous templates (or endogenous wild-type sequences) during HDR, leading to unwanted mutations (Fig. 2B).

Urine is a preferred body fluid for proteome analysis, as it is quite stable, probably due to the fact that it is "stored" for hours in the bladder, hence proteolytic degradation by endogenous proteases, a major obstacle in proteomics studies focusing on blood [ 37], may be essentially complete by the time of voiding [ 38, 39].

However, in addition to the immunological barriers, porcine endogenous retroviruses (PERVs) created an obstacle for safe transplantation.

The lack of a PINK1 specific and consistent antibody capable of detecting all forms of endogenous PINK1 is a prominent obstacle in the PD field and it will have to be an area of intense focus in the next few years if we are to truly understand all aspects of PINK1 function.

FA proteins appear to play a central role in the response to both endogenous and exogenous sources of replication obstacles.

Attempts to control endogenous mammalian genes, however, face a significant obstacle in the form of chromatin.

DNA damage is constantly generated from endogenous and exogenous sources in cells and poses a major obstacle to vital cellular processes of replication and transcription, possibly leading to mutation and cell death.