Sentence examples for endogenous negative from inspiring English sources

MicroRNAs (miRNAs) are noncoding RNAs that provide an endogenous negative feedback mechanism for translation of messenger RNA (mRNA) into protein.

The p53 pathway in HNSCC can be compromised through multiple mechanisms including gene mutations, hyperactivation of endogenous negative p53 regulators and by the human papillomavirus E6 protein.

These results identify Nab2 as a novel endogenous negative regulator of Egr-1-dependent TGF-β signaling responsible for setting the intensity of fibrotic responses.

VE-statin/egfl7 is also an endogenous negative regulator of elastogenesis which prevents the deposition of elastin by endothelial cells [24].

In contrast to the constitutively expressed long splice variants HOMER1b/c, the short splice variant HOMER1a is induced by neurotransmission activity as an IEG, acts as endogenous negative modulator of the mGluR/IP3 receptor signaling complex and prevents excessive glutamate-induced neuronal activity [37].

Inadequate production of these endogenous negative regulators may also contribute to the pathogenesis of sepsis [ 14].

Thus the short variant of CaRF could potentially act as an endogenous dominant negative of CaRF-dependent transcription.

Later work by the same group showed a similar phenotype in mice in which one NFAT5 allele had been truncated and the expressed product was suggested to act as an endogenous dominant negative [24].

These data are consistent with reports that endogenous gram negative bacteria tonically prime insulin production in rats [53] and consistent with data that treatment of islets ex vivo with LPS promotes β-cell insulin production [21].

We previously demonstrated in a mouse embryonic carcinoma cell model that an endogenous dominant negative RARα mutant, lacking part of the E domain harboring the RA-binding domain, induced concerted epigenetic repression of both RARβ2 and CYP26A1, encoding for a RA hydrolase involved in RA catabolism [8].

Thus, BAMBI serves as an endogenous dominant negative receptor [ 13].