All the transgenes would reside on an independent minichromosome, not linked to any endogenous genes; thus linkage drag can be avoided.
Bak activation and oligomerization was monitored by disulfide linkage between endogenous cysteines (C14 and C166) in hBak, as previously described.
As revealed by reducing and non-reducing SDS-PAGE and native gel immunoblots, both recombinant and endogenous otolin have similar disulfide linkages.
DNA damage also induces the attachment of ubiquitin to a subfraction of endogenous SNEV via a thiolester linkage, and this modification disrupts the interaction between SNEV and both Cdc5L and PLRG1 demonstrating that DNA damage can profoundly affect the structure of the SNEV core complex [ 24].
This paper adds the standard input output linkages into a multi-sector endogenous growth model to study the interaction effects between linkages and technology adoption for aggregate productivity and for income per capita.
GNE1023 inhibition of both overexpressed and endogenous LRRK2 resulted in increased ubiquitination and linkages to Lys and Lys.
Although linkage-specific antibodies (four of which are available, M1, K11, K48, and K63) provide an opportunity to explore the impact of chain linkage on the fate of endogenous polyUb-modified proteins, it is difficult to differentiate between homotypic and heterotypic chains.
To understand the molecular basis of EDCs and endogenous estrogens on developing organisms, we must understand the linkages between exposure levels, genes responsive to EDCs, and the adverse effects induced by these chemicals.
How is the length and linkage specificity of ubiquitin chains controlled on endogenous substrates in vivo ?
Specifically, we focus on i) the design of high molar mass, main-chain degradable polymers as drug carriers; ii) drug delivery using endogenous macromolecules such as albumin; iii) the choice of biodegradable linkages for drug delivery, and iv) the emerging interest in delivery of short-lived gasotransmitters.
The findings indicate that measurement context affected the linkages between the experimentally manipulated brand and price information and subsequent endogenous variables as well as linkages among the endogenous variables.
