Sometimes the endogenous limits in this development strategy were reinforced by international conditions (drop in world prices of commodities) so that crises also occurred even if the economy was not growing rapidly.
However, variations in preanalytical processing of samples and lack of established endogenous controls limit the comparability of results [21].
The low activity of available LD in grains is due to its combination with endogenous inhibitors, limit dextrinase inhibitor (LDI) [ 7].
Because BMP signalling is required for the induction of PGCs and blood, this result suggests that the levels of endogenous BMP limit the production of these cell types in the VMZ.
To elucidate endogenous barriers limiting this process, we systematically dissected human cellular reprogramming by combining a genome-wide RNAi screen, innovative computational methods, extensive single-hit validation, and mechanistic investigation of relevant pathways and networks.
However, whether endogenous AMPK limits mTORC1 in vivo has yet to be determined.
Expression of Twist1 in TH1 cells acts as an endogenous regulator limiting the proinflammatory potential of TH1 cells in the continuous presence of antigen with repeated activation of NFAT and NF-κB.
Although exposure levels may be low and EDCs are typically less potent than endogenous hormones, limited knowledge of product formulations, exposure levels, and the biological activity and toxicity of chemical constituents alone and in combination make it difficult to assess risks associated with product use.
A biosynthetic route for production in Escherichia coli has been developed (Moon et al., 2009), but previous work with the glucaric acid pathway has indicated that competition with endogenous metabolism may limit carbon flux into the pathway.
However, the fact that MMP-2 C233A, which was secreted at a lower level (Fig. 3B) induced higher clone activation (Fig. 1B), suggests that protein secretion may nonetheless limit endogenous antigen presentation.
