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This underscores the need for effective, non-toxic strategies that can eliminate the residual tumor cells and also, perhaps, immunize the endogenous immune system against the tumor.
These therapies may depend on an existing endogenous immune response, and although anti-tumor immunity can be stimulated in a subgroup of patients, we do not know to what extent the remaining patients harbor tumor-reactive T cells.
It was shown previously that following passive immunization, animals that survived anthrax challenge developed an endogenous immune response toward PA [26].
This study highlights the therapeutic potential for modulating endogenous immune response through cell-surface glycan engineering.
Organoid-based propagation of primary tumor epithelium en bloc with endogenous immune stroma should enable immuno-oncology investigations within the TME and facilitate personalized immunotherapy testing.
Since most prokaryotes harbor native CRISPR-Cas systems, genome engineering can be achieved by harnessing these endogenous immune systems.
Similar(13)
Cancer vaccines are designed to elicit an endogenous adaptive immune response that can successfully recognize and eliminate residual or recurring tumors.
Although gynecologic cancers have not been historically classified as immunogenic tumors, growing evidence has shown that they are in fact able to elicit endogenous antitumor immune responses suggesting that patients with these cancers may benefit from immunotherapy.
To substantiate this idea, we explored whether an endogenous adaptive immune system was required for MPTP-induced nigrostriatal degeneration.
These cases are instructive, suggesting manipulation of an established, endogenous, existing immune response.
Similar techniques may ultimately lead to increased effectiveness of endogenous antitumor immune responses.
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