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At the endogenous frequency, the average work output for the 23 24 min perfusion interval was not significantly different in MECR transgenic hearts (36.2±11.6) from that of wild-type controls (38.3±5.9), although the heart rate tended to be slower in the transgenic hearts (2.95 Hz±0.70, mean±SD) than in controls (3.43±0.69, mean±SD) (Figure 4A).
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Because we reached the endogenous deletion frequency of the background DNA, we were unable to test lower frequencies in the reconstruction experiment.
This result supports the model that endogenous low frequency oscillatory dynamics are relevant to the brain's response to exogenous stimulation.
The mechanical work output of the hearts was monitored at three workload levels: at their endogenous beating frequency (3.2 3.8 Hz), pacing at 5 Hz, and pacing at 7.5 Hz.
Genomic DNA was isolated from HCT 116 cells, chosen for its relatively low endogenous deletion frequency of 1.8 × 10−7.
Various scientific studies suggest the presence of an endogenous low frequency electromagnetic field in living organisms around the 0.4 2.0 kHz region [ 1– 5] and thus a valid question arises whether external sources (stimuli) of these frequencies could influence the underlying biological processes.
Here, we sought to examine whether the mutant transgene resulted in changes in the relative abundance of splice variants in channel-forming genes which may account for the reduction in endogenous PC firing frequency.
The default network (DN) is an ensemble of brain regions that shows deactivation during a wide range of externally-cued tasks compared to a task-free resting-state, and exhibits coherent low-frequency endogenous resting-state fluctuations [1] [14].
Despite the high frequency of endogenous PD-1+ TIM-3+ CD8+ T cells following virus administration, antibody blockade did not improve survival.
Previously, the application of transcranial direct current stimulation, oscillating at the frequency of endogenous slow oscillations, during SWS enhanced memory consolidation for a hippocampus dependent task in human subjects and suggested a causal role of SOs for sleep dependent memory consolidation (Marshall et al., 2006).
To this end, we used a novel, intermittent tACS protocol and investigated the strength of the aftereffect as a function of phase continuity between successive tACS episodes, as well as the match between stimulation frequency and endogenous α-frequency.
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