Sentence examples for endogenous essential from inspiring English sources

Coupling CRISPRi to cell growth by regulating an endogenous essential gene (ispA) increased isoprene (C5) production.

In the search for new anticancer agents with effective chemotherapeutic spectrum and reduced toxicity, new substances based on endogenous (essential) metals have shown promising initial results.

More generally, while previous studies have approached CRISPR as a microbial immune system, another important role of the system may be to exert pressure on endogenous and essential genes, resulting in dramatic changes in the genome content and physiology of the host species.

For the majority of redox enzymes, NADH and its phosphorylated form NADPH are essential endogenous coenzymes (Nakamura and Matsuda, 2002).

Known translation repressing RNA GQs were engineered into human VEGF IRES A replacing the endogenous GQ domain essential for translation.

The results suggest that a high degree of mobility near the active site and in the helix carrying the endogenous cysteine is essential for full catalytic efficiency in the cold-adapted AP.

In vivo analysis of BMDC-treated ischemic limbs and cutaneous wounds revealed that the production of monocyte chemoattractant factor 1 by exogenous and endogenous BMDCs is essential for BMDC-mediated vascular growth and tissue healing, while the inability of BMDCs to produce tumor necrosis factor α appears to play a lesser but still meaningful role.

The pharmacological and molecular features of snake toxins not only led to the discovery of essential endogenous molecules involved in the regulation of blood pressure, but also allowed John Vane (a Nobel laureate) to spotlight the angiotensin I-converting enzyme (ACE) as a target for a drug to treat human hypertension.

In conclusion, while endogenous IFNs are essential for control of B.anthracis germination and lethality, administration of exogenous IFNs appear to increase the local inflammatory response, thereby increasing mortality.

Moreover, studies of AKT expressed at endogenous levels are essential.

Endogenous GCs are essential for the maintenance of blood glucose levels.