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Tracking cell-cycle progression in live cells within their endogenous environment has been an outstanding challenge.
The most promising current technology is genome editing, which allows researchers to edit DNA sequences directly in their endogenous environment.
Due to their large hydrophobic membrane spanning regions and often very short loops exposed on the surface of the cells, generation of antibodies able to recognize the receptors in the endogenous environment has been difficult.
However, there is also evidence that NSCs lose or gain abilities when isolated from their endogenous environment.
Although many of the identified growth factors have been implicated in neuronal survival, the mechanisms underlying their interaction with the endogenous environment is yet to be elucidated.
Cell based strategies for central nervous system (CNS) repair are inherently combinatorial in nature, in that they replace dead or dying cells, provide a substrate for endogenous neural growth and angiogenesis, and provide neurotrophic support for the endogenous environment.
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The skin as an interface organ between the internal and external environments is plagued by oxidative radicals generated from both exogenous and endogenous environments as a result of ongoing pro- and anti-oxidant disequilibrium. 1 The human immunodeficiency virus (HIV) is a known oxidative stress inducer that depletes its host of selenium.
A reduction in cellular complexity will in turn decrease the complexity of the endogenous signaling environment and the diversity of inductive cell:cell interactions that can occur.
We hypothesized that xenoestrogen chemicals may influence breast tissue more strongly in a low endogenous hormone environment.
The nutritional and endogenous chemical environment affects development of the lung and can result in altered function in the adult.
(2) Does the endogenous oestrogen environment, as reflected by menopausal status and body weight, affect this association?
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