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isn't the result of an endogenous disease.
Continued refinement of optimal experimental design for gerontologic studies requires an astute choice of mouse models that limits the interference from endogenous disease and maximizes genetic diversity.
A combination of these small seasonal effects may be amplified by dynamical resonance with the endogenous disease cycles.
The results obtained using these novel approaches provide new insights into template design for gene correction and the relationships between multiple DSBR pathways at a single endogenous disease gene.
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Non-invasive assessment of the dynamics of gene regulation is of interest for the detection of endogenous disease-specific biological alterations (e.g., signal transduction) and for monitoring the induction and regulation of therapeutic genes (e.g., gene therapy).
α2M can bind to a range of endogenous disease-associated proteins including the amyloid β peptide (Aβ1 42) [6], prion proteins [7] and β2-microglobulin [8], which are the main components of deposits found in Alzheimer's disease (AD), spongiform encephalopathies and dialysis-related amyloidosis, respectively [9].
P. acnes as a cause of sarcoidosis can therefore be classified within the group of endogenous diseases that results from hypersensitivity.
To illustrate, knowledge KAP is assumed to depend on the endogenous dummy disease outbreak in the village or not (defined as ifdisease in Table 5) and a K × 1 vector of explanatory variables (including the constant term), x i.
To more closely mimic the endogenous SCA7 disease state, a heterozygous model was established in which both full-length wild-type and mutant atxn7 cDNA expression plasmids were co-transfected into HEK293 cells (Figure 1B).
Given that the initial data shown (Figures 2 and Figure S1A) and that obtained by others [17] was acquired from screens of short target mRNA sequences, we sought to model the endogenous SCA7 disease more closely by studying shRNAs targeting the full-length endogenous atxn7 cDNA transcript (Figure 3).
Several reports show a relation between the severity of head injury and serum S-100B protein (S-100B) levels in trauma patients, but there are few data about S-100B in endogenous cerebral disease.
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