Sentence examples for endogenous compared from inspiring English sources

First, we performed siRNA-mediated silencing and overexpression of mPGES-1, which enabled us to address the complementary effects of endogenous compared with overexpressed mPGES-1 in cancer cells on tumorigenic potentials (growth, invasion and ECM binding in vitro and tumour xenograft propagation in vivo).

However, IDH2 R172 mutants were only weakly able to pull down endogenous IDH2 compared to IDH2-WT in these cells (Fig. 1c).

Our mice express the R155H mutant VCP gene at an endogenous level compared to previous models which overexpresses the mutant allele.

In NIH-3T3 fibroblasts, which contain very low levels of endogenous p110δ compared to leukocytes, p110δ could not be induced by TNF, the proteasome inhibitor PS-341, UV irradiation, osmotic stress or the glucocorticoid dexamethasone (data not shown).

Interestingly, we detected that the expression of these mutant CHFR proteins had a completely different result upon the growth of HeLa cells, which express endogenous CHFR, compared with HCT116 and RKO cells (Fig. 2C).

Whether the reduced effect on transcriptional activation in targeting an endogenous gene, compared with a reporter system, is a general phenomenon or whether the effect is target gene-specific remains to be studied systematically.

Again, nonphosphorylable NBR1 showed a slight increase of interaction with endogenous SQSTM1 compared with wild-type or phosphomimetic NBR1.

However, it should be recognized that transfection experiments result in relatively high expression levels of endogenous GH compared with physiological conditions.

qPCR results confirm that siRNAs against individual WNT genes reduce endogenous transcripts compared to siRNAs against WLS or a non-silencing control siRNA (Supporting Information Fig S6).

There was a significantly higher yield of clones from PNT1a cells, which express higher levels of endogenous clusterin, compared to PC-3 cells.

38 We have established that men with COPD have significantly lower levels of endogenous TT compared with controls (WMD was −3.21 nmol/L (−5.18 to −1.23)).