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The mode of action of Omega-3 can be intercepted pharmacologically at different levels with agents that scavenge free reactive oxygen, block their generation, or enhance endogenous antioxidant capabilities [ 35].
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T-AOC reflects the overall cellular endogenous antioxidative capability for both enzymatic and nonenzymatic antioxidants [ 19].
Oxidative stress is produced when the balance is disturbed between an upload of free radical/reactive oxygen/nitrogen species (ROS/RNS) from in vivo formation and from in vitro environmental carcinogens, and the capability of endogenous antioxidant defense mechanisms to remove those reactive species [ 30, 31].
To investigate changes in endogenous antioxidant function age, we measured total antioxidant capacity in-situ using the Trolox assay.
Bilirubin in turn is well-established as an important endogenous antioxidant and thus contributes to the total antioxidant capacity [ 17].
Glutathione is a major endogenous antioxidant in biological systems.
In the bovine lens, ET concentrations, about 7 mM,10 exceed those of glutathione, generally regarded as the most abundant endogenous antioxidant.
We first asked whether exposure to nanoceria affected the expression of endogenous antioxidant proteins as this could confound the results.
Studies also reported that Dendrobium officinale polysaccharides showed antioxidant capabilities.
Regressed tumor progression was correlated with pronounced endogenous antioxidant enzyme superoxide dismutase and catalase in-vivo.
In addition, PCA-induced survival is also mediated with the activating of endogenous antioxidant enzymes.
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