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The structure of phylogenetic trees, together with the presence of amino acid signatures, is consistent with a common origin of the strains circulating 2008 2009, supporting the concept of endemic circulation of WNV in Italy (6 ).
Given an ensemble of stuttering chains, information about the number of cases in each chain can be used to infer R0, which is of crucial importance for monitoring the risk that a disease will emerge to establish endemic circulation.
Additionally, studies are needed on the accumulation of mutations within-host and in short chains of transmission in mammals (22 25), even when endemic circulation has not been observed.
Large cities support endemic circulation and periodically seed epidemics in smaller towns [18].
It extends the duration of endemic circulation in the metapopulation as a whole.
Therefore, community transmission can lead to efficient endemic circulation even in the absence of local, home based, transmission.
Similar(16)
Thus, despite the reduction of endemic MV circulation, importation of MV from other continents caused prolonged circulation and large outbreaks after their introduction into unvaccinated and highly mobile communities.
Based on known risk factors such as pig herd structure and neighborhood conditions, an index characterizing individual herds' potential for endemic virus circulation and reinfection was designed.
Molecular characterization of measles viruses (MV) helps to identify transmission pathways of the virus and to document persistence or interruption of endemic virus circulation.
The youngest persons (<10 years of age) had the lowest risk for past exposure, which is consistent with endemic VEEV circulation.
These data indicate long-term enzootic and endemic VEEV circulation in the region and continued risk for disease in equines and humans.
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