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Hepatocellular carcinoma (HCC) represents an endemic burden worldwide, partially due to delayed diagnosis and multiple risk factors that contribute to a permanent high incidence [1], [2].
Hepatocellular carcinoma (HCC) represents an endemic burden worldwide.
This stands in contrast to the long-established endemic burden of typhoid in South and Southeast Asia [ 1, 5, 22].
However, securing resources and support for intervention will rely on convincing data about the endemic burden of HEV disease, particularly its role in maternal and perinatal mortality.
Although the endemic burden of typhoid fever in South and Southeast Asia has long been recognized, less is known about the burden of disease in sub-Saharan Africa.
HCC represents an endemic burden worldwide, partially due to delayed diagnosis and multiple risk factors that contribute to a permanent high incidence [ 9, 10], stressing the need to characterize potential new early biomarkers.
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However, strong systems will mitigate epidemic outbreaks and reduce endemic disease burdens.
A two-regime time-behavior and a non-monotonic relation between spread of recessive resistant genes and mixing were observed for a range of key biological parameters (e.g. basic reproductive number, natural parasite mortality rate, endemic mean worm burden and initial prevalence of resistant genes) and intervention-related parameters (e.g. coverage and drug-induced parasite mortality rate).
Likewise, where zoonotic pathogens contribute to the endemic diarrhea disease burden through exposure to animal excreta, 4 conventional WASH interventions focused on exposure to human excreta alone may have limited health impacts.
Burkitt lymphoma (BL) is >90% EBV-associated when this pediatric cancer is diagnosed in regions heavily burden by endemic Plasmodium falciparum malaria and thus has been geographically classified as endemic BL.
And animals may suffer in factory farms (though they bear a big burden of endemic diseases in pastoral systems).
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CEO of Professional Science Editing for Scientists @ prosciediting.com