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Second, our present study is powered for a cardiovascular end point to detect a 25% difference in left ventricular ejection fraction.
Unfortunately, the trial did not meet its primary end point to detect a difference in the time to reach definition of improvement (DOI) in the early vs. late arms.
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Guideline-compliant studies must use appropriate routes and validated end points to detect adverse outcomes, for example, changes in survival, growth and/or development, body and/or organ weights, histopathology, and systemic and reproductive organ functions.
The primary end point was to detect at least 10% of pCRs after chemohormonal treatment.
We employed a fluorescence microscopy-based end point assay to detect nuclear defects in interphase cells that could be indicative for defects in cell division.
The primary end point was to detect recurrence after 9 and 15 months of follow up in each group, on the basis of the intent-to-treat principle, that is, data from all randomised patients were analysed according to the strategy group to which they had been assigned when randomised.
All plants were kept in a greenhouse at a temperature ranging from 25 to 28°C, with a natural photoperiod and monitored bimonthly by end-point PCR to detect CaLam or CaLas.
On the basis of past experience and assuming a normal distribution and a coefficient of variation of approximately 25% for tumour growth rate, we determined that at least seven mice per group would be necessary to have 80% power at the two-sided 5% significance level to detect difference in the end-points evaluated12,40.
Linking end points to resistance.
Metz et al. [ 14] used the minimum cost path of the specified start and end points in vessel to detect the coronary arteries centerline.
Thus, a major limitation of the Tyl studies is the failure to measure more meaningful and sensitive end points in order to detect the effects of low-dose BPA exposure, which are often not macroscopic in nature.
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