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The end point is attained when the color changes sharply from green blue to wine red.
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Small amount of NAOH was further titrated until the end point was attained, marked by a colour changed from colourless to pink.
One company highlighted that adaptive design is not possible in therapeutic areas where end points are attained slowly while recruitment is fast.
The primary end point is progression-free survival; OS is the key secondary end point.
The end point is July 31 , 2008
Note, no end point is achieved.
This did provide increased confidence that the end of life end point had been attained, but the relatively low starting cohort numbers (20 per genotype per gender) precluded extensive histopathological assessment.
The secondary end point was the percentage of patients attaining ≥3 treatment targets and their impacts on clinical outcomes.
The primary end point was the number of patients attaining CR, and secondary end points were the rates of complete remission with persistent thrombocytopenia (CRp), relapse-free survival (RFS), overall survival (OS), and time to platelet- and time to ANC recovery.
The primary end point was mortality.
Primary end point was three-year survival.
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